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KMID : 0614620100550050336
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Korean Journal of Gastroenterology
2010 Volume.55 No. 5 p.336 ~ p.339
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A Case of Ulcerative Colitis Found in a Patient Whose Parent has Crohn’s Disease
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Kwak Jae-Wuk
Lee Kang-Moon
Chung Woo-Chul
Paik Chang-Nyol
Chang U-Im
Kim Jin-Dong
Jung Sung-Hoon
Yang Jin-Mo
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Abstract
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Inflammatory bowel diseases (IBD) is heterogeneous, chronic relapsing disorder. Inappropriate and exaggerated immune
response for the luminal antigen is known as a main pathogenesis. Genetic, infectious, and environmental factors are responsible for unbalanced immune response, but the definite pathogenesis is still unclear. Genetic factor is the most important role of all. That is based on high concordance rate of identical twins and family history. The incident rate and prevalence of IBD for the Asian population is relatively lower than Western population, and the lack of NOD2 or TLR4 genetic polymorphisms in Korea and Japanese population suggests the difference in genetic background between Asian and Western population. In Korea, the case of familial aggregation of IBD is pretty rare. We report a case of the daughter with ulcerative colitis and her mother with Crohn’s disease who have a -159C/T promoter polymorphism of CD14 gene for IBD.
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KEYWORD
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Familial aggregation, Inflammatory bowel diseases, Genetics
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